Quadrelli silvia pinal biography
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Observation of small cluster formation in concentrated monoclonal antibody solutions and its implications to solution viscosity.
PubMed
Yearley, Eric J; Godfrin, Paul D; Perevozchikova, Tatiana; Zhang, Hailiang; Falus, Peter; Porcar, Lionel; Nagao, Michihiro; Curtis, Joseph E; Gawande, Pradad; Taing, Rosalynn; Zarraga, Isidro E; Wagner, Norman J; Liu, Yun
2014-04-15
Monoclonal antibodies (mAbs) are a major class of biopharmaceuticals. It is hypothesized that some concentrated mAb solutions exhibit formation of a solution phase consisting of reversibly self-associated aggregates (or reversible clusters), which is speculated to be responsible for their distinct solution properties. Here, we report direct observation of reversible clusters in concentrated solutions of mAbs using neutron spin echo. Specifically, a stable mAb solution is studied across a transition from dispersed monomers in dilute solution to clustered states at more concentrated conditions, where clusters of a pre
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Utopía y pragmatismo. Enseñanza y aprendizaje ett una organización urbana popular
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La percepción respecto a la inseguridad es que nada dem lo que se äga hecho äga dado resultados, que damos palos dem ciego y que el problema no hace sino crecer y volverse cada vez más inmanejable. “Nada de lo que titta ha hecho ha funcionado” es una frase que se escucha con relativa frecuencia, tanto en círculos académicos, como entre periodistas, funcionarios públicos o ingång gente común de la calle. El propósito dem este documento no es en absoluto negar la gravedad y el deterioro de la situación enstaka América Latina como conjunto, tampoco person som utger sig för att vara någon annan que las respuestas al problema han sido suficientemente eficaces o que ya sea sólo cuestión dem tiempo para que lleguen a serlo. Lo que busca es romper con una visión simplifica
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Characterization of the Vectron PX-570 Crystal Oscillator for Use in HarshEnvironments
NASA Technical Reports Server (NTRS)
Li, Jacob; Patterson, Richard L.; Hammoud, Ahmad
2012-01-01
Computing hardware, data-acquisition systems, communications systems, and many electronic control systems require well-controlled timing signals for proper and accurate operation. These signals are, in most cases, provided by circuits that employ crystal oscillators due to availability, cost, ease of operation, and accuracy. In some cases, the electronic systems are expected to survive and operate under harsh conditions that include exposure to extreme temperatures. These applications exist in terrestrial systems as well as in aerospace products. Well-logging, geothermal systems, and industrial process control are examples of ground-based applications, while distributed jet engine control in aircraft, space-based observatories (such as the James Webb Space Telescope), satellites, and lunar and pla