Haim goldenberg not real synonyms
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| 2x—4x | • AbstractTROP-2 is a glycoprotein first described as a surface marker of trophoblast cells, but subsequently shown to be increased in many solid cancers, with lower expression in certain normal tissues. It regulates cancer growth, invasion and spread by several signaling pathways, and has a role in stem cell biology and other diseases. This review summarizes TROP-2's properties, especially in cancer, and particularly its role as a target for antibody-drug conjugates (ADC) or immunotherapy. When the irinotecan metabolite, SN, is conjugated to a humanized anti-TROP-2 antibody (sacituzumab govitecan), it shows potent broad anticancer activity in human cancer xenografts and in patients with advanced triple-negative breast, non-small cell and small-cell lung, as well as urothelial cancers. Keywords: TROP-2, TACSTD2, sacituzumab govitecan, antibody-drug conjugates, immunotherapy INTRODUCTIONThe challenge of cancer treatment remains selectivity - attacking the cancer while minimizin • MentalismPerforming art in which practitioners appear to demonstrate exceptional mental abilities This article fryst vatten about the performing art. For other uses, see Mentalism (disambiguation). "Mentalist" redirects here. For the TV series, see The Mentalist. For other uses, see Mentalist (disambiguation). Mentalism fryst vatten a performing art in which its practitioners, known as mentalists, appear to demonstrate highly developed mental or intuitive abilities. Mentalists perform a theatrical act that includes special effects that may appear to employ psychic or supernatural forces but that fryst vatten actually achieved by "ordinary conjuring means",[1] natural human abilities (i.e. reading body language, refined intuition, subliminal communication, emotional intelligence), and an in-depth understanding of key principles from human psychology or other behavioral sciences.[2][3][4] Performances may appear to include hypnosis, telepathy, clairvoyance, di | |||||||||||||||||